{"id":3526,"date":"2021-11-25T06:03:10","date_gmt":"2021-11-25T06:03:10","guid":{"rendered":"https:\/\/www.oferreiter.com\/?p=3526"},"modified":"2023-10-29T09:31:34","modified_gmt":"2023-10-29T09:31:34","slug":"are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis","status":"publish","type":"post","link":"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/","title":{"rendered":"Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis"},"content":{"rendered":"\r\n\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=200&amp;term=Snast+I&amp;cauthor_id=29098604\"><span style=\"font-weight: 400;\">Igor Snast<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29098604\/#full-view-affiliation-1\"><span style=\"font-weight: 400;\">1<\/span><\/a><span style=\"font-weight: 400;\">,\u00a0<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=200&amp;term=Reiter+O&amp;cauthor_id=29098604\"><span style=\"font-weight: 400;\">Ofer Reiter<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29098604\/#full-view-affiliation-1\"><span style=\"font-weight: 400;\">1<\/span><\/a><span style=\"font-weight: 400;\">,\u00a0<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=200&amp;term=Hodak+E&amp;cauthor_id=29098604\"><span style=\"font-weight: 400;\">Emmilia Hodak<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29098604\/#full-view-affiliation-1\"><span style=\"font-weight: 400;\">1<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29098604\/#full-view-affiliation-2\"><span style=\"font-weight: 400;\">2<\/span><\/a><span style=\"font-weight: 400;\">,\u00a0<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=200&amp;term=Friedland+R&amp;cauthor_id=29098604\"><span style=\"font-weight: 400;\">Rivka Friedland<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29098604\/#full-view-affiliation-3\"><span style=\"font-weight: 400;\">3<\/span><\/a><span style=\"font-weight: 400;\">,\u00a0<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=200&amp;term=Mimouni+D&amp;cauthor_id=29098604\"><span style=\"font-weight: 400;\">Daniel Mimouni<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29098604\/#full-view-affiliation-4\"><span style=\"font-weight: 400;\">4<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29098604\/#full-view-affiliation-5\"><span style=\"font-weight: 400;\">5<\/span><\/a><span style=\"font-weight: 400;\">,\u00a0<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=200&amp;term=Leshem+YA&amp;cauthor_id=29098604\"><span style=\"font-weight: 400;\">Yael Anne Leshem<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29098604\/#full-view-affiliation-1\"><span style=\"font-weight: 400;\">1<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29098604\/#full-view-affiliation-2\"><span style=\"font-weight: 400;\">2<\/span><\/a>\r\n\r\n<span style=\"font-weight: 400;\">Affiliations\u00a0expand<\/span>\r\n<ul>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">PMID:\u00a0<\/span><span style=\"font-weight: 400;\">29098604<\/span><\/li>\r\n<\/ul>\r\n<span style=\"font-weight: 400;\">\u00a0<\/span>\r\n<ul>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">DOI:\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1007\/s40257-017-0324-7\"><span style=\"font-weight: 400;\">10.1007\/s40257-017-0324-7<\/span><\/a><\/li>\r\n<\/ul>\r\n<h2><span style=\"font-weight: 400;\">Abstract<\/span><\/h2>\r\n<b>Background:\u00a0<\/b><span style=\"font-weight: 400;\">Current systemic treatments for atopic dermatitis (AD) offer limited efficacy and are often restricted by safety concerns. Biologics may address the unmet need for improved AD therapeutics.<\/span>\r\n\r\n<b>Objective:\u00a0<\/b><span style=\"font-weight: 400;\">The aim of this study was to evaluate the efficacy and safety of biologic agents in AD.<\/span>\r\n\r\n<b>Methods:\u00a0<\/b><span style=\"font-weight: 400;\">A systematic review and meta-analysis of studies evaluating AD patients treated with biologics was performed. The primary outcome was the Eczema Area and Severity Index (EASI)-75 response, while secondary outcomes were SCOring Atopic Dermatitis (SCORAD)-75, EASI-50, SCORAD-50, Investigator Global Assessment 0\/1 responses, change in responses from baseline, and adverse events.<\/span>\r\n\r\n<b>Results:\u00a0<\/b><span style=\"font-weight: 400;\">We included 13 randomized controlled trials (RCTs) and 10 observational studies evaluating nine biologics. High-quality evidence was available for dupilumab, nemolizumab and ustekinumab. Pooling five studies, at weeks 12-16 dupilumab 300 mg every week to every 2 weeks achieved EASI-75 responses of 55%, superior to placebo [relative risk (RR) 3.3, 95% confidence interval (CI) 2.9-3.6]. Nemolizumab had similar EASI-75 responses as placebo, but significantly improved pruritus. In online reports, lebrikizumab demonstrated superior EASI-50 responses versus placebo (RR 1.3, 95% CI 1.04-1.7), while tralokinumab had superior SCORAD-50 responses versus placebo, with borderline significance (RR 1.7, 95% CI 0.97-3.1). In two RCTs each, omalizumab and ustekinumab were comparable with placebo, while antithymic stromal lymphopoietin receptor, infliximab, and rituximab lacked adequate evidence of efficacy. All medications had a comparable safety profile to placebo.<\/span>\r\n\r\n<b>Limitations:\u00a0<\/b><span style=\"font-weight: 400;\">Lack of RCTs and the use of variable outcome measures limited conclusions.<\/span>\r\n\r\n<b>Conclusion:\u00a0<\/b><span style=\"font-weight: 400;\">Dupilumab is currently the only biologic with robust evidence of efficacy in AD. Nemolizumab, lebrikizumab, and tralokinumab show promise but further data are needed. Longer follow-up and larger studies will establish their safety profile.<\/span>\r\n\r\n\r\n\r\n\r\n<figure class=\"wp-block-image size-large is-resized\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-2006\" style=\"width: 840px; height: 1170px;\" src=\"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d52cab92c3cc4576b9f7962da6b20e0fmv2-735x1024.webp\" alt=\"\" width=\"840\" height=\"1170\" srcset=\"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d52cab92c3cc4576b9f7962da6b20e0fmv2-735x1024.webp 735w, https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d52cab92c3cc4576b9f7962da6b20e0fmv2-215x300.webp 215w, https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d52cab92c3cc4576b9f7962da6b20e0fmv2-768x1070.webp 768w, https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d52cab92c3cc4576b9f7962da6b20e0fmv2.webp 1064w\" sizes=\"(max-width: 840px) 100vw, 840px\" \/><\/figure>\r\n\r\n\r\n\r\n\r\n. Am J Clin Dermatol. 2017 Nov 2.\r\n\r\n","protected":false},"excerpt":{"rendered":"<p>Igor Snast\u00a01,\u00a0Ofer Reiter\u00a01,\u00a0Emmilia Hodak\u00a01\u00a02,\u00a0Rivka Friedland\u00a03,\u00a0Daniel Mimouni\u00a04\u00a05,\u00a0Yael Anne Leshem\u00a01\u00a02 Affiliations\u00a0expand PMID:\u00a029098604 \u00a0 DOI:\u00a010.1007\/s40257-017-0324-7 Abstract Background:\u00a0Current systemic treatments for atopic dermatitis (AD) offer limited efficacy and are often restricted by safety concerns. Biologics may address the unmet need for improved AD therapeutics. Objective:\u00a0The aim of this study was to evaluate the efficacy and safety of biologic agents [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2717,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3526","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis - \u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis - \u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8\" \/>\n<meta property=\"og:description\" content=\"Igor Snast\u00a01,\u00a0Ofer Reiter\u00a01,\u00a0Emmilia Hodak\u00a01\u00a02,\u00a0Rivka Friedland\u00a03,\u00a0Daniel Mimouni\u00a04\u00a05,\u00a0Yael Anne Leshem\u00a01\u00a02 Affiliations\u00a0expand PMID:\u00a029098604 \u00a0 DOI:\u00a010.1007\/s40257-017-0324-7 Abstract Background:\u00a0Current systemic treatments for atopic dermatitis (AD) offer limited efficacy and are often restricted by safety concerns. Biologics may address the unmet need for improved AD therapeutics. Objective:\u00a0The aim of this study was to evaluate the efficacy and safety of biologic agents [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/\" \/>\n<meta property=\"og:site_name\" content=\"\u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8\" \/>\n<meta property=\"article:published_time\" content=\"2021-11-25T06:03:10+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-10-29T09:31:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d52cab92c3cc4576b9f7962da6b20e0fmv2.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1064\" \/>\n\t<meta property=\"og:image:height\" content=\"1482\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"newoferr_admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"newoferr_admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/\"},\"author\":{\"name\":\"newoferr_admin\",\"@id\":\"https:\/\/www.oferreiter.com\/en\/#\/schema\/person\/ed72a0d5185a8c3e30dc667f8b4de8a4\"},\"headline\":\"Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis\",\"datePublished\":\"2021-11-25T06:03:10+00:00\",\"dateModified\":\"2023-10-29T09:31:34+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/\"},\"wordCount\":304,\"publisher\":{\"@id\":\"https:\/\/www.oferreiter.com\/en\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d52cab92c3cc4576b9f7962da6b20e0fmv2.webp\",\"articleSection\":[\"Published Research\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/\",\"url\":\"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/\",\"name\":\"Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis - \u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8\",\"isPartOf\":{\"@id\":\"https:\/\/www.oferreiter.com\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d52cab92c3cc4576b9f7962da6b20e0fmv2.webp\",\"datePublished\":\"2021-11-25T06:03:10+00:00\",\"dateModified\":\"2023-10-29T09:31:34+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/#primaryimage\",\"url\":\"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d52cab92c3cc4576b9f7962da6b20e0fmv2.webp\",\"contentUrl\":\"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d52cab92c3cc4576b9f7962da6b20e0fmv2.webp\",\"width\":1064,\"height\":1482},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u05d3\u05e3 \u05d4\u05d1\u05d9\u05ea\",\"item\":\"https:\/\/www.oferreiter.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.oferreiter.com\/en\/#website\",\"url\":\"https:\/\/www.oferreiter.com\/en\/\",\"name\":\"\u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8\",\"description\":\"\u05d0\u05d1\u05d7\u05d5\u05df \u05d5\u05d8\u05d9\u05e4\u05d5\u05dc \u05de\u05d5\u05e7\u05d3\u05dd \u05d1\u05e1\u05e8\u05d8\u05df \u05d4\u05e2\u05d5\u05e8\",\"publisher\":{\"@id\":\"https:\/\/www.oferreiter.com\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.oferreiter.com\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.oferreiter.com\/en\/#organization\",\"name\":\"\u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8\",\"url\":\"https:\/\/www.oferreiter.com\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.oferreiter.com\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/03\/cropped-ofer-logo-1.png\",\"contentUrl\":\"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/03\/cropped-ofer-logo-1.png\",\"width\":300,\"height\":57,\"caption\":\"\u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8\"},\"image\":{\"@id\":\"https:\/\/www.oferreiter.com\/en\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.oferreiter.com\/en\/#\/schema\/person\/ed72a0d5185a8c3e30dc667f8b4de8a4\",\"name\":\"newoferr_admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.oferreiter.com\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/82b6cc160cfdab6a75653dcc1cf0626024031008b3094758ac53e8f6014d4199?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/82b6cc160cfdab6a75653dcc1cf0626024031008b3094758ac53e8f6014d4199?s=96&d=mm&r=g\",\"caption\":\"newoferr_admin\"},\"sameAs\":[\"https:\/\/www.oferreiter.com\"],\"url\":\"https:\/\/www.oferreiter.com\/en\/author\/newoferr_admin\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis - \u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/","og_locale":"en_US","og_type":"article","og_title":"Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis - \u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8","og_description":"Igor Snast\u00a01,\u00a0Ofer Reiter\u00a01,\u00a0Emmilia Hodak\u00a01\u00a02,\u00a0Rivka Friedland\u00a03,\u00a0Daniel Mimouni\u00a04\u00a05,\u00a0Yael Anne Leshem\u00a01\u00a02 Affiliations\u00a0expand PMID:\u00a029098604 \u00a0 DOI:\u00a010.1007\/s40257-017-0324-7 Abstract Background:\u00a0Current systemic treatments for atopic dermatitis (AD) offer limited efficacy and are often restricted by safety concerns. Biologics may address the unmet need for improved AD therapeutics. Objective:\u00a0The aim of this study was to evaluate the efficacy and safety of biologic agents [&hellip;]","og_url":"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/","og_site_name":"\u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8","article_published_time":"2021-11-25T06:03:10+00:00","article_modified_time":"2023-10-29T09:31:34+00:00","og_image":[{"width":1064,"height":1482,"url":"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d52cab92c3cc4576b9f7962da6b20e0fmv2.webp","type":"image\/webp"}],"author":"newoferr_admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"newoferr_admin","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/#article","isPartOf":{"@id":"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/"},"author":{"name":"newoferr_admin","@id":"https:\/\/www.oferreiter.com\/en\/#\/schema\/person\/ed72a0d5185a8c3e30dc667f8b4de8a4"},"headline":"Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis","datePublished":"2021-11-25T06:03:10+00:00","dateModified":"2023-10-29T09:31:34+00:00","mainEntityOfPage":{"@id":"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/"},"wordCount":304,"publisher":{"@id":"https:\/\/www.oferreiter.com\/en\/#organization"},"image":{"@id":"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/#primaryimage"},"thumbnailUrl":"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d52cab92c3cc4576b9f7962da6b20e0fmv2.webp","articleSection":["Published Research"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/","url":"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/","name":"Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis - \u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8","isPartOf":{"@id":"https:\/\/www.oferreiter.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/#primaryimage"},"image":{"@id":"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/#primaryimage"},"thumbnailUrl":"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d52cab92c3cc4576b9f7962da6b20e0fmv2.webp","datePublished":"2021-11-25T06:03:10+00:00","dateModified":"2023-10-29T09:31:34+00:00","breadcrumb":{"@id":"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/#primaryimage","url":"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d52cab92c3cc4576b9f7962da6b20e0fmv2.webp","contentUrl":"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d52cab92c3cc4576b9f7962da6b20e0fmv2.webp","width":1064,"height":1482},{"@type":"BreadcrumbList","@id":"https:\/\/www.oferreiter.com\/en\/are-biologics-efficacious-in-atopic-dermatitis-a-systematic-review-and-meta-analysis\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u05d3\u05e3 \u05d4\u05d1\u05d9\u05ea","item":"https:\/\/www.oferreiter.com\/en\/"},{"@type":"ListItem","position":2,"name":"Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis"}]},{"@type":"WebSite","@id":"https:\/\/www.oferreiter.com\/en\/#website","url":"https:\/\/www.oferreiter.com\/en\/","name":"\u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8","description":"\u05d0\u05d1\u05d7\u05d5\u05df \u05d5\u05d8\u05d9\u05e4\u05d5\u05dc \u05de\u05d5\u05e7\u05d3\u05dd \u05d1\u05e1\u05e8\u05d8\u05df \u05d4\u05e2\u05d5\u05e8","publisher":{"@id":"https:\/\/www.oferreiter.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.oferreiter.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.oferreiter.com\/en\/#organization","name":"\u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8","url":"https:\/\/www.oferreiter.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.oferreiter.com\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/03\/cropped-ofer-logo-1.png","contentUrl":"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/03\/cropped-ofer-logo-1.png","width":300,"height":57,"caption":"\u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8"},"image":{"@id":"https:\/\/www.oferreiter.com\/en\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.oferreiter.com\/en\/#\/schema\/person\/ed72a0d5185a8c3e30dc667f8b4de8a4","name":"newoferr_admin","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.oferreiter.com\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/82b6cc160cfdab6a75653dcc1cf0626024031008b3094758ac53e8f6014d4199?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/82b6cc160cfdab6a75653dcc1cf0626024031008b3094758ac53e8f6014d4199?s=96&d=mm&r=g","caption":"newoferr_admin"},"sameAs":["https:\/\/www.oferreiter.com"],"url":"https:\/\/www.oferreiter.com\/en\/author\/newoferr_admin\/"}]}},"_links":{"self":[{"href":"https:\/\/www.oferreiter.com\/en\/wp-json\/wp\/v2\/posts\/3526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.oferreiter.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.oferreiter.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.oferreiter.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.oferreiter.com\/en\/wp-json\/wp\/v2\/comments?post=3526"}],"version-history":[{"count":0,"href":"https:\/\/www.oferreiter.com\/en\/wp-json\/wp\/v2\/posts\/3526\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.oferreiter.com\/en\/wp-json\/wp\/v2\/media\/2717"}],"wp:attachment":[{"href":"https:\/\/www.oferreiter.com\/en\/wp-json\/wp\/v2\/media?parent=3526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.oferreiter.com\/en\/wp-json\/wp\/v2\/categories?post=3526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.oferreiter.com\/en\/wp-json\/wp\/v2\/tags?post=3526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}