{"id":3603,"date":"2021-11-25T07:24:00","date_gmt":"2021-11-25T07:24:00","guid":{"rendered":"https:\/\/www.oferreiter.com\/?p=3603"},"modified":"2023-10-29T11:37:00","modified_gmt":"2023-10-29T11:37:00","slug":"the-differences-in-clinical-dermoscopic-features-between-in-nevus-associated-and-de-novo-melanomas-2","status":"publish","type":"post","link":"https:\/\/www.oferreiter.com\/en\/the-differences-in-clinical-dermoscopic-features-between-in-nevus-associated-and-de-novo-melanomas-2\/","title":{"rendered":"The differences in clinical &#038; dermoscopic features between in nevus-associated and de-novo melanomas"},"content":{"rendered":"\r\n<p id=\"viewer-foo\">Reiter O, Kurtansky N, Nanda JK, Busam KJ, Scope A, Musthaq S, Marghoob AA.<\/p>\r\n\r\n<h2><span style=\"font-weight: 400;\">Abstract<\/span><\/h2>\r\n<b>Background:\u00a0<\/b><span style=\"font-weight: 400;\">Nevus-associated melanomas (NAM) account for 30% of all melanomas and are associated with younger age and with thinner Breslow thickness. Previous studies of NAM dermoscopy found conflicting results.<\/span>\r\n\r\n<b>Objective:\u00a0<\/b><span style=\"font-weight: 400;\">To compare the clinical and dermoscopic features of NAM and de novo melanomas (DNM), stratified by melanoma thickness, in a relatively large cohort of patients.<\/span>\r\n\r\n<b>Methods:\u00a0<\/b><span style=\"font-weight: 400;\">A cross-sectional study of all melanomas biopsied between 2004 and 2019 at a large cancer centre. Lesions were categorized as in situ and invasive NAM or DNM. Dermoscopic images were reviewed and annotated. Associations between melanoma subtype and dermoscopic features were analysed via logistic regression modelling. Bivariate analyses were conducted using non-parametric bootstrap and chi-squared methods.<\/span>\r\n\r\n<b>Results:\u00a0<\/b><span style=\"font-weight: 400;\">The study included 160 NAM (86 in situ and 74 invasive) and 218 DNM (109 in situ and 109 invasive). NAM were associated with younger age, greater likelihood of being present on the torso, and thinner Breslow thickness. NAM were 2.5 times more likely to show a negative pigment network than DNM. In situ NAM were 2.1 and two times more likely to display dermoscopic area without definable structures and tan structureless areas than DNM, respectively. In situ melanomas were more likely to present a pigment network, and invasive melanomas more commonly presented scar-like depigmentation and shiny white structures. Streaks, blotches and shiny white structures were associated with deeper Breslow depth.<\/span>\r\n\r\n<b>Conclusions:\u00a0<\/b><span style=\"font-weight: 400;\">Even though the nevus component of NAM could not be identified dermoscopically in the current series, negative pigment network, tan structureless areas and areas without definable structures are dermoscopic clues for NAM.<\/span>\r\n\r\n\r\n\r\n\r\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\r\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"721\" height=\"1024\" data-id=\"1652\" class=\"wp-image-1652\" src=\"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d5ee6f1e23854b1ab1adf619641325camv2-721x1024.webp\" alt=\"\" srcset=\"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d5ee6f1e23854b1ab1adf619641325camv2-721x1024.webp 721w, https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d5ee6f1e23854b1ab1adf619641325camv2-211x300.webp 211w, https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d5ee6f1e23854b1ab1adf619641325camv2-768x1090.webp 768w, https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/08\/44fc9a_d5ee6f1e23854b1ab1adf619641325camv2.webp 791w\" sizes=\"(max-width: 721px) 100vw, 721px\" \/><\/figure>\r\n<\/figure>\r\n","protected":false},"excerpt":{"rendered":"<p>\u05e8\u05e7\u05e2: \u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea \u05d4\u05e7\u05e9\u05d5\u05e8\u05d5\u05ea \u05dc\u05e0\u05d1\u05d5\u05e1 (NAM) \u05de\u05d4\u05d5\u05d5\u05ea 30% \u05de\u05db\u05dc\u05dc \u05d4\u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea \u05d5\u05e7\u05e9\u05d5\u05e8\u05d5\u05ea \u05dc\u05d2\u05d9\u05dc \u05e6\u05e2\u05d9\u05e8 \u05d9\u05d5\u05ea\u05e8 \u05d5\u05dc\u05e2\u05d5\u05d1\u05d9 \u05d1\u05e8\u05e1\u05dc\u05d5 \u05d3\u05e7 \u05d9\u05d5\u05ea\u05e8. \u05de\u05d7\u05e7\u05e8\u05d9\u05dd \u05e7\u05d5\u05d3\u05de\u05d9\u05dd \u05e9\u05dc \u05d4\u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9\u05d4 \u05e9\u05dc NAM \u05de\u05e6\u05d0\u05d5 \u05ea\u05d5\u05e6\u05d0\u05d5\u05ea \u05e1\u05d5\u05ea\u05e8\u05d5\u05ea.<br \/>\n\u05de\u05d8\u05e8\u05d4: \u05dc\u05d4\u05e9\u05d5\u05d5\u05ea \u05d0\u05ea \u05d4\u05de\u05d0\u05e4\u05d9\u05d9\u05e0\u05d9\u05dd \u05d4\u05e7\u05dc\u05d9\u05e0\u05d9\u05d9\u05dd \u05d5\u05d4\u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9\u05d9\u05dd \u05e9\u05dc NAM \u05d5\u05e9\u05dc \u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea \u05e9\u05d4\u05d5\u05e4\u05d9\u05e2\u05d5 \u05d3\u05d4 \u05e0\u05d5\u05d1\u05d5 (DNM), \u05de\u05e8\u05d5\u05d1\u05d3\u05d5\u05ea \u05dc\u05e4\u05d9 \u05e2\u05d5\u05d1\u05d9 \u05d4\u05de\u05dc\u05e0\u05d5\u05de\u05d4, \u05d1\u05e7\u05d1\u05d5\u05e6\u05d4 \u05d2\u05d3\u05d5\u05dc\u05d4 \u05d9\u05d7\u05e1\u05d9\u05ea \u05e9\u05dc \u05d7\u05d5\u05dc\u05d9\u05dd.<br \/>\n\u05e9\u05d9\u05d8\u05d5\u05ea: \u05de\u05d7\u05e7\u05e8 \u05d7\u05ea\u05da \u05e9\u05dc \u05db\u05dc \u05d4\u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea \u05e9\u05e2\u05d1\u05e8\u05d5 \u05d1\u05d9\u05d5\u05e4\u05e1\u05d9\u05d4 \u05d1\u05d9\u05df 2004 \u05dc-2019 \u05d1\u05de\u05e8\u05db\u05d6 \u05e1\u05e8\u05d8\u05df \u05d2\u05d3\u05d5\u05dc. \u05d4\u05e0\u05d2\u05e2\u05d9\u05dd \u05e1\u05d5\u05d5\u05d2\u05d5 \u05db-NAM \u05d0\u05d5 DNM \u05d5\u05dc\u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea \u05e9\u05d4\u05df in situ \u05d0\u05d5 \u05e4\u05d5\u05dc\u05e9\u05e0\u05d9\u05d5\u05ea. \u05ea\u05de\u05d5\u05e0\u05d5\u05ea \u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9\u05d5\u05ea \u05e0\u05d1\u05d3\u05e7\u05d5 \u05d5\u05ea\u05d5\u05d9\u05d2\u05d5. \u05d4\u05e7\u05e9\u05e8\u05d9\u05dd \u05d1\u05d9\u05df \u05ea\u05ea-\u05e1\u05d5\u05d2 \u05d4\u05de\u05dc\u05e0\u05d5\u05de\u05d4 \u05dc\u05de\u05d0\u05e4\u05d9\u05d9\u05e0\u05d9\u05dd \u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9\u05d9\u05dd \u05e0\u05d5\u05ea\u05d7\u05d5 \u05d1\u05d0\u05de\u05e6\u05e2\u05d5\u05ea \u05de\u05d5\u05d3\u05dc \u05e8\u05d2\u05e8\u05e1\u05d9\u05d4 \u05dc\u05d5\u05d2\u05d9\u05e1\u05d8\u05d9. \u05e0\u05d9\u05ea\u05d5\u05d7\u05d9\u05dd \u05d3\u05d5-\u05de\u05e9\u05ea\u05e0\u05d9\u05dd \u05e0\u05e2\u05e8\u05db\u05d5 \u05ea\u05d5\u05da \u05e9\u05d9\u05de\u05d5\u05e9 \u05d1\u05e9\u05d9\u05d8\u05d5\u05ea \u05d0\u05ea\u05d7\u05d5\u05dc \u05dc\u05d0-\u05e4\u05e8\u05de\u05d8\u05e8\u05d9\u05d5\u05ea \u05d5\u05d1\u05e9\u05d9\u05d8\u05ea \u05d7\u05d9 \u05d1\u05e8\u05d9\u05d1\u05d5\u05e2.<br \/>\n\u05ea\u05d5\u05e6\u05d0\u05d5\u05ea: \u05d4\u05de\u05d7\u05e7\u05e8 \u05db\u05dc\u05dc 160 NAM (86 in situ \u05d5-74 \u05e4\u05d5\u05dc\u05e9\u05e0\u05d9) \u05d5-218 DNM (109 in situ \u05d5-109 \u05e4\u05d5\u05dc\u05e9\u05e0\u05d9). NAM \u05d4\u05d9\u05d5 \u05d1\u05d0\u05e1\u05d5\u05e1\u05d9\u05d0\u05e6\u05d9\u05d4 \u05dc\u05d2\u05d9\u05dc \u05e6\u05e2\u05d9\u05e8 \u05d9\u05d5\u05ea\u05e8, \u05e1\u05d1\u05d9\u05e8\u05d5\u05ea \u05d2\u05d1\u05d5\u05d4\u05d4 \u05d9\u05d5\u05ea\u05e8 \u05dc\u05d4\u05d9\u05de\u05e6\u05d0\u05d5\u05ea \u05e2\u05dc \u05d4\u05d2\u05d5 \u05d5\u05e2\u05d5\u05d1\u05d9 \u05d1\u05e8\u05e1\u05dc\u05d5 \u05d3\u05e7 \u05d9\u05d5\u05ea\u05e8. NAM \u05d4\u05d9\u05d5 \u05d1\u05e1\u05d1\u05d9\u05e8\u05d5\u05ea \u05d2\u05d1\u05d5\u05d4\u05d4 \u05e4\u05d9 2.5 \u05dc\u05d4\u05e8\u05d0\u05d5\u05ea \u05e8\u05e9\u05ea \u05e4\u05d9\u05d2\u05de\u05e0\u05d8\u05e8\u05d9\u05ea \u05e9\u05dc\u05d9\u05dc\u05d9\u05ea \u05de\u05d0\u05e9\u05e8 DNM. NAM \u05e9\u05d4\u05d9\u05d5 in situ \u05d4\u05d9\u05d5 \u05d1\u05e1\u05d1\u05d9\u05e8\u05d5\u05ea \u05d2\u05d1\u05d5\u05d4\u05d4 \u05e4\u05d9 2.1 \u05d5\u05e4\u05d9 \u05e9\u05e0\u05d9\u05d9\u05dd \u05dc\u05d4\u05e6\u05d9\u05d2 \u05d0\u05d6\u05d5\u05e8 \u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9 \u05dc\u05dc\u05d0 \u05de\u05d1\u05e0\u05d9\u05dd \u05e0\u05d9\u05ea\u05e0\u05d9\u05dd \u05dc\u05d4\u05d2\u05d3\u05e8\u05d4 \u05d5\u05d0\u05d6\u05d5\u05e8\u05d9\u05dd \u05d7\u05e1\u05e8\u05d9 \u05de\u05d1\u05e0\u05d4 \u05d7\u05d5\u05de\u05d9\u05dd \u05d1\u05d4\u05d9\u05e8\u05d9\u05dd \u05de\u05d0\u05e9\u05e8 DNM, \u05d1\u05d4\u05ea\u05d0\u05de\u05d4. \u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea in situ \u05d4\u05e6\u05d2\u05d9\u05e2\u05d5 \u05d1\u05e1\u05d1\u05d9\u05e8\u05d5\u05ea \u05d2\u05d1\u05d5\u05d4\u05d4 \u05d9\u05d5\u05ea\u05e8 \u05e8\u05e9\u05ea \u05e4\u05d9\u05d2\u05de\u05e0\u05d8\u05e8\u05d9\u05ea, \u05d5\u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea \u05e4\u05d5\u05dc\u05e9\u05e0\u05d9\u05d5\u05ea \u05d4\u05e6\u05d9\u05d2\u05d5 \u05d1\u05d3\u05e8\u05da \u05db\u05dc\u05dc \u05d3\u05d4-\u05e4\u05d9\u05d2\u05de\u05e0\u05d8\u05e6\u05d9\u05d4 \u05d3\u05de\u05d5\u05d9\u05ea \u05e6\u05dc\u05e7\u05ea \u05d5\u05de\u05d1\u05e0\u05d9\u05dd \u05dc\u05d1\u05e0\u05d9\u05dd \u05de\u05d1\u05e8\u05d9\u05e7\u05d9\u05dd. \u05e4\u05e1\u05d9\u05dd, \u05db\u05ea\u05de\u05d9\u05dd \u05d5\u05de\u05d1\u05e0\u05d9\u05dd \u05dc\u05d1\u05e0\u05d9\u05dd \u05de\u05d1\u05e8\u05d9\u05e7\u05d9\u05dd \u05d4\u05d9\u05d5 \u05e7\u05e9\u05d5\u05e8\u05d9\u05dd \u05dc\u05e2\u05d5\u05de\u05e7 \u05d1\u05e8\u05e1\u05dc\u05d5 \u05e2\u05de\u05d5\u05e7 \u05d9\u05d5\u05ea\u05e8.<br \/>\n\u05de\u05e1\u05e7\u05e0\u05d5\u05ea: \u05dc\u05de\u05e8\u05d5\u05ea \u05e9\u05dc\u05d0 \u05e0\u05d9\u05ea\u05df \u05d4\u05d9\u05d4 \u05dc\u05d6\u05d4\u05d5\u05ea \u05d0\u05ea \u05de\u05e8\u05db\u05d9\u05d1 \u05d4\u05e0\u05d1\u05d5\u05e1 \u05e9\u05dc NAM \u05d1\u05d0\u05d5\u05e4\u05df \u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9 \u05d1\u05e1\u05d3\u05e8\u05d4 \u05d4\u05e0\u05d5\u05db\u05d7\u05d9\u05ea, \u05e8\u05e9\u05ea \u05e4\u05d9\u05d2\u05de\u05e0\u05d8\u05d9\u05dd \u05e9\u05dc\u05d9\u05dc\u05d9\u05ea, \u05d0\u05d6\u05d5\u05e8\u05d9\u05dd \u05d7\u05e1\u05e8\u05d9 \u05de\u05d1\u05e0\u05d4 \u05d7\u05d5\u05de\u05d9\u05dd \u05d1\u05d4\u05d9\u05e8\u05d9\u05dd \u05d5\u05d0\u05d6\u05d5\u05e8\u05d9\u05dd \u05dc\u05dc\u05d0 \u05de\u05d1\u05e0\u05d9\u05dd \u05e0\u05d9\u05ea\u05e0\u05d9\u05dd \u05dc\u05d4\u05d2\u05d3\u05e8\u05d4 \u05d4\u05dd \u05e8\u05de\u05d6\u05d9\u05dd \u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9\u05d9\u05dd \u05dc- NAM.<\/p>\n","protected":false},"author":1,"featured_media":2604,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3603","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-published-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The differences in clinical &amp; dermoscopic features between in nevus-associated and de-novo melanomas - \u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.oferreiter.com\/en\/the-differences-in-clinical-dermoscopic-features-between-in-nevus-associated-and-de-novo-melanomas-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The differences in clinical &amp; dermoscopic features between in nevus-associated and de-novo melanomas - \u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8\" \/>\n<meta property=\"og:description\" content=\"\u05e8\u05e7\u05e2: \u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea \u05d4\u05e7\u05e9\u05d5\u05e8\u05d5\u05ea \u05dc\u05e0\u05d1\u05d5\u05e1 (NAM) \u05de\u05d4\u05d5\u05d5\u05ea 30% \u05de\u05db\u05dc\u05dc \u05d4\u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea \u05d5\u05e7\u05e9\u05d5\u05e8\u05d5\u05ea \u05dc\u05d2\u05d9\u05dc \u05e6\u05e2\u05d9\u05e8 \u05d9\u05d5\u05ea\u05e8 \u05d5\u05dc\u05e2\u05d5\u05d1\u05d9 \u05d1\u05e8\u05e1\u05dc\u05d5 \u05d3\u05e7 \u05d9\u05d5\u05ea\u05e8. \u05de\u05d7\u05e7\u05e8\u05d9\u05dd \u05e7\u05d5\u05d3\u05de\u05d9\u05dd \u05e9\u05dc \u05d4\u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9\u05d4 \u05e9\u05dc NAM \u05de\u05e6\u05d0\u05d5 \u05ea\u05d5\u05e6\u05d0\u05d5\u05ea \u05e1\u05d5\u05ea\u05e8\u05d5\u05ea. \u05de\u05d8\u05e8\u05d4: \u05dc\u05d4\u05e9\u05d5\u05d5\u05ea \u05d0\u05ea \u05d4\u05de\u05d0\u05e4\u05d9\u05d9\u05e0\u05d9\u05dd \u05d4\u05e7\u05dc\u05d9\u05e0\u05d9\u05d9\u05dd \u05d5\u05d4\u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9\u05d9\u05dd \u05e9\u05dc NAM \u05d5\u05e9\u05dc \u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea \u05e9\u05d4\u05d5\u05e4\u05d9\u05e2\u05d5 \u05d3\u05d4 \u05e0\u05d5\u05d1\u05d5 (DNM), \u05de\u05e8\u05d5\u05d1\u05d3\u05d5\u05ea \u05dc\u05e4\u05d9 \u05e2\u05d5\u05d1\u05d9 \u05d4\u05de\u05dc\u05e0\u05d5\u05de\u05d4, \u05d1\u05e7\u05d1\u05d5\u05e6\u05d4 \u05d2\u05d3\u05d5\u05dc\u05d4 \u05d9\u05d7\u05e1\u05d9\u05ea \u05e9\u05dc \u05d7\u05d5\u05dc\u05d9\u05dd. \u05e9\u05d9\u05d8\u05d5\u05ea: \u05de\u05d7\u05e7\u05e8 \u05d7\u05ea\u05da \u05e9\u05dc \u05db\u05dc \u05d4\u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea \u05e9\u05e2\u05d1\u05e8\u05d5 \u05d1\u05d9\u05d5\u05e4\u05e1\u05d9\u05d4 \u05d1\u05d9\u05df 2004 \u05dc-2019 \u05d1\u05de\u05e8\u05db\u05d6 \u05e1\u05e8\u05d8\u05df \u05d2\u05d3\u05d5\u05dc. \u05d4\u05e0\u05d2\u05e2\u05d9\u05dd \u05e1\u05d5\u05d5\u05d2\u05d5 \u05db-NAM \u05d0\u05d5 DNM \u05d5\u05dc\u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea \u05e9\u05d4\u05df in situ \u05d0\u05d5 \u05e4\u05d5\u05dc\u05e9\u05e0\u05d9\u05d5\u05ea. \u05ea\u05de\u05d5\u05e0\u05d5\u05ea \u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9\u05d5\u05ea \u05e0\u05d1\u05d3\u05e7\u05d5 \u05d5\u05ea\u05d5\u05d9\u05d2\u05d5. \u05d4\u05e7\u05e9\u05e8\u05d9\u05dd \u05d1\u05d9\u05df \u05ea\u05ea-\u05e1\u05d5\u05d2 \u05d4\u05de\u05dc\u05e0\u05d5\u05de\u05d4 \u05dc\u05de\u05d0\u05e4\u05d9\u05d9\u05e0\u05d9\u05dd \u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9\u05d9\u05dd \u05e0\u05d5\u05ea\u05d7\u05d5 \u05d1\u05d0\u05de\u05e6\u05e2\u05d5\u05ea \u05de\u05d5\u05d3\u05dc \u05e8\u05d2\u05e8\u05e1\u05d9\u05d4 \u05dc\u05d5\u05d2\u05d9\u05e1\u05d8\u05d9. \u05e0\u05d9\u05ea\u05d5\u05d7\u05d9\u05dd \u05d3\u05d5-\u05de\u05e9\u05ea\u05e0\u05d9\u05dd \u05e0\u05e2\u05e8\u05db\u05d5 \u05ea\u05d5\u05da \u05e9\u05d9\u05de\u05d5\u05e9 \u05d1\u05e9\u05d9\u05d8\u05d5\u05ea \u05d0\u05ea\u05d7\u05d5\u05dc \u05dc\u05d0-\u05e4\u05e8\u05de\u05d8\u05e8\u05d9\u05d5\u05ea \u05d5\u05d1\u05e9\u05d9\u05d8\u05ea \u05d7\u05d9 \u05d1\u05e8\u05d9\u05d1\u05d5\u05e2. \u05ea\u05d5\u05e6\u05d0\u05d5\u05ea: \u05d4\u05de\u05d7\u05e7\u05e8 \u05db\u05dc\u05dc 160 NAM (86 in situ \u05d5-74 \u05e4\u05d5\u05dc\u05e9\u05e0\u05d9) \u05d5-218 DNM (109 in situ \u05d5-109 \u05e4\u05d5\u05dc\u05e9\u05e0\u05d9). NAM \u05d4\u05d9\u05d5 \u05d1\u05d0\u05e1\u05d5\u05e1\u05d9\u05d0\u05e6\u05d9\u05d4 \u05dc\u05d2\u05d9\u05dc \u05e6\u05e2\u05d9\u05e8 \u05d9\u05d5\u05ea\u05e8, \u05e1\u05d1\u05d9\u05e8\u05d5\u05ea \u05d2\u05d1\u05d5\u05d4\u05d4 \u05d9\u05d5\u05ea\u05e8 \u05dc\u05d4\u05d9\u05de\u05e6\u05d0\u05d5\u05ea \u05e2\u05dc \u05d4\u05d2\u05d5 \u05d5\u05e2\u05d5\u05d1\u05d9 \u05d1\u05e8\u05e1\u05dc\u05d5 \u05d3\u05e7 \u05d9\u05d5\u05ea\u05e8. NAM \u05d4\u05d9\u05d5 \u05d1\u05e1\u05d1\u05d9\u05e8\u05d5\u05ea \u05d2\u05d1\u05d5\u05d4\u05d4 \u05e4\u05d9 2.5 \u05dc\u05d4\u05e8\u05d0\u05d5\u05ea \u05e8\u05e9\u05ea \u05e4\u05d9\u05d2\u05de\u05e0\u05d8\u05e8\u05d9\u05ea \u05e9\u05dc\u05d9\u05dc\u05d9\u05ea \u05de\u05d0\u05e9\u05e8 DNM. NAM \u05e9\u05d4\u05d9\u05d5 in situ \u05d4\u05d9\u05d5 \u05d1\u05e1\u05d1\u05d9\u05e8\u05d5\u05ea \u05d2\u05d1\u05d5\u05d4\u05d4 \u05e4\u05d9 2.1 \u05d5\u05e4\u05d9 \u05e9\u05e0\u05d9\u05d9\u05dd \u05dc\u05d4\u05e6\u05d9\u05d2 \u05d0\u05d6\u05d5\u05e8 \u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9 \u05dc\u05dc\u05d0 \u05de\u05d1\u05e0\u05d9\u05dd \u05e0\u05d9\u05ea\u05e0\u05d9\u05dd \u05dc\u05d4\u05d2\u05d3\u05e8\u05d4 \u05d5\u05d0\u05d6\u05d5\u05e8\u05d9\u05dd \u05d7\u05e1\u05e8\u05d9 \u05de\u05d1\u05e0\u05d4 \u05d7\u05d5\u05de\u05d9\u05dd \u05d1\u05d4\u05d9\u05e8\u05d9\u05dd \u05de\u05d0\u05e9\u05e8 DNM, \u05d1\u05d4\u05ea\u05d0\u05de\u05d4. \u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea in situ \u05d4\u05e6\u05d2\u05d9\u05e2\u05d5 \u05d1\u05e1\u05d1\u05d9\u05e8\u05d5\u05ea \u05d2\u05d1\u05d5\u05d4\u05d4 \u05d9\u05d5\u05ea\u05e8 \u05e8\u05e9\u05ea \u05e4\u05d9\u05d2\u05de\u05e0\u05d8\u05e8\u05d9\u05ea, \u05d5\u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea \u05e4\u05d5\u05dc\u05e9\u05e0\u05d9\u05d5\u05ea \u05d4\u05e6\u05d9\u05d2\u05d5 \u05d1\u05d3\u05e8\u05da \u05db\u05dc\u05dc \u05d3\u05d4-\u05e4\u05d9\u05d2\u05de\u05e0\u05d8\u05e6\u05d9\u05d4 \u05d3\u05de\u05d5\u05d9\u05ea \u05e6\u05dc\u05e7\u05ea \u05d5\u05de\u05d1\u05e0\u05d9\u05dd \u05dc\u05d1\u05e0\u05d9\u05dd \u05de\u05d1\u05e8\u05d9\u05e7\u05d9\u05dd. \u05e4\u05e1\u05d9\u05dd, \u05db\u05ea\u05de\u05d9\u05dd \u05d5\u05de\u05d1\u05e0\u05d9\u05dd \u05dc\u05d1\u05e0\u05d9\u05dd \u05de\u05d1\u05e8\u05d9\u05e7\u05d9\u05dd \u05d4\u05d9\u05d5 \u05e7\u05e9\u05d5\u05e8\u05d9\u05dd \u05dc\u05e2\u05d5\u05de\u05e7 \u05d1\u05e8\u05e1\u05dc\u05d5 \u05e2\u05de\u05d5\u05e7 \u05d9\u05d5\u05ea\u05e8. \u05de\u05e1\u05e7\u05e0\u05d5\u05ea: \u05dc\u05de\u05e8\u05d5\u05ea \u05e9\u05dc\u05d0 \u05e0\u05d9\u05ea\u05df \u05d4\u05d9\u05d4 \u05dc\u05d6\u05d4\u05d5\u05ea \u05d0\u05ea \u05de\u05e8\u05db\u05d9\u05d1 \u05d4\u05e0\u05d1\u05d5\u05e1 \u05e9\u05dc NAM \u05d1\u05d0\u05d5\u05e4\u05df \u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9 \u05d1\u05e1\u05d3\u05e8\u05d4 \u05d4\u05e0\u05d5\u05db\u05d7\u05d9\u05ea, \u05e8\u05e9\u05ea \u05e4\u05d9\u05d2\u05de\u05e0\u05d8\u05d9\u05dd \u05e9\u05dc\u05d9\u05dc\u05d9\u05ea, \u05d0\u05d6\u05d5\u05e8\u05d9\u05dd \u05d7\u05e1\u05e8\u05d9 \u05de\u05d1\u05e0\u05d4 \u05d7\u05d5\u05de\u05d9\u05dd \u05d1\u05d4\u05d9\u05e8\u05d9\u05dd \u05d5\u05d0\u05d6\u05d5\u05e8\u05d9\u05dd \u05dc\u05dc\u05d0 \u05de\u05d1\u05e0\u05d9\u05dd \u05e0\u05d9\u05ea\u05e0\u05d9\u05dd \u05dc\u05d4\u05d2\u05d3\u05e8\u05d4 \u05d4\u05dd \u05e8\u05de\u05d6\u05d9\u05dd \u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9\u05d9\u05dd \u05dc- NAM.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.oferreiter.com\/en\/the-differences-in-clinical-dermoscopic-features-between-in-nevus-associated-and-de-novo-melanomas-2\/\" \/>\n<meta property=\"og:site_name\" content=\"\u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 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\u05e6\u05e2\u05d9\u05e8 \u05d9\u05d5\u05ea\u05e8 \u05d5\u05dc\u05e2\u05d5\u05d1\u05d9 \u05d1\u05e8\u05e1\u05dc\u05d5 \u05d3\u05e7 \u05d9\u05d5\u05ea\u05e8. \u05de\u05d7\u05e7\u05e8\u05d9\u05dd \u05e7\u05d5\u05d3\u05de\u05d9\u05dd \u05e9\u05dc \u05d4\u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9\u05d4 \u05e9\u05dc NAM \u05de\u05e6\u05d0\u05d5 \u05ea\u05d5\u05e6\u05d0\u05d5\u05ea \u05e1\u05d5\u05ea\u05e8\u05d5\u05ea. \u05de\u05d8\u05e8\u05d4: \u05dc\u05d4\u05e9\u05d5\u05d5\u05ea \u05d0\u05ea \u05d4\u05de\u05d0\u05e4\u05d9\u05d9\u05e0\u05d9\u05dd \u05d4\u05e7\u05dc\u05d9\u05e0\u05d9\u05d9\u05dd \u05d5\u05d4\u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9\u05d9\u05dd \u05e9\u05dc NAM \u05d5\u05e9\u05dc \u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea \u05e9\u05d4\u05d5\u05e4\u05d9\u05e2\u05d5 \u05d3\u05d4 \u05e0\u05d5\u05d1\u05d5 (DNM), \u05de\u05e8\u05d5\u05d1\u05d3\u05d5\u05ea \u05dc\u05e4\u05d9 \u05e2\u05d5\u05d1\u05d9 \u05d4\u05de\u05dc\u05e0\u05d5\u05de\u05d4, \u05d1\u05e7\u05d1\u05d5\u05e6\u05d4 \u05d2\u05d3\u05d5\u05dc\u05d4 \u05d9\u05d7\u05e1\u05d9\u05ea \u05e9\u05dc \u05d7\u05d5\u05dc\u05d9\u05dd. \u05e9\u05d9\u05d8\u05d5\u05ea: \u05de\u05d7\u05e7\u05e8 \u05d7\u05ea\u05da \u05e9\u05dc \u05db\u05dc \u05d4\u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea \u05e9\u05e2\u05d1\u05e8\u05d5 \u05d1\u05d9\u05d5\u05e4\u05e1\u05d9\u05d4 \u05d1\u05d9\u05df 2004 \u05dc-2019 \u05d1\u05de\u05e8\u05db\u05d6 \u05e1\u05e8\u05d8\u05df \u05d2\u05d3\u05d5\u05dc. \u05d4\u05e0\u05d2\u05e2\u05d9\u05dd \u05e1\u05d5\u05d5\u05d2\u05d5 \u05db-NAM \u05d0\u05d5 DNM \u05d5\u05dc\u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea \u05e9\u05d4\u05df in situ \u05d0\u05d5 \u05e4\u05d5\u05dc\u05e9\u05e0\u05d9\u05d5\u05ea. \u05ea\u05de\u05d5\u05e0\u05d5\u05ea \u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9\u05d5\u05ea \u05e0\u05d1\u05d3\u05e7\u05d5 \u05d5\u05ea\u05d5\u05d9\u05d2\u05d5. \u05d4\u05e7\u05e9\u05e8\u05d9\u05dd \u05d1\u05d9\u05df \u05ea\u05ea-\u05e1\u05d5\u05d2 \u05d4\u05de\u05dc\u05e0\u05d5\u05de\u05d4 \u05dc\u05de\u05d0\u05e4\u05d9\u05d9\u05e0\u05d9\u05dd \u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9\u05d9\u05dd \u05e0\u05d5\u05ea\u05d7\u05d5 \u05d1\u05d0\u05de\u05e6\u05e2\u05d5\u05ea \u05de\u05d5\u05d3\u05dc \u05e8\u05d2\u05e8\u05e1\u05d9\u05d4 \u05dc\u05d5\u05d2\u05d9\u05e1\u05d8\u05d9. \u05e0\u05d9\u05ea\u05d5\u05d7\u05d9\u05dd \u05d3\u05d5-\u05de\u05e9\u05ea\u05e0\u05d9\u05dd \u05e0\u05e2\u05e8\u05db\u05d5 \u05ea\u05d5\u05da \u05e9\u05d9\u05de\u05d5\u05e9 \u05d1\u05e9\u05d9\u05d8\u05d5\u05ea \u05d0\u05ea\u05d7\u05d5\u05dc \u05dc\u05d0-\u05e4\u05e8\u05de\u05d8\u05e8\u05d9\u05d5\u05ea \u05d5\u05d1\u05e9\u05d9\u05d8\u05ea \u05d7\u05d9 \u05d1\u05e8\u05d9\u05d1\u05d5\u05e2. \u05ea\u05d5\u05e6\u05d0\u05d5\u05ea: \u05d4\u05de\u05d7\u05e7\u05e8 \u05db\u05dc\u05dc 160 NAM (86 in situ \u05d5-74 \u05e4\u05d5\u05dc\u05e9\u05e0\u05d9) \u05d5-218 DNM (109 in situ \u05d5-109 \u05e4\u05d5\u05dc\u05e9\u05e0\u05d9). NAM \u05d4\u05d9\u05d5 \u05d1\u05d0\u05e1\u05d5\u05e1\u05d9\u05d0\u05e6\u05d9\u05d4 \u05dc\u05d2\u05d9\u05dc \u05e6\u05e2\u05d9\u05e8 \u05d9\u05d5\u05ea\u05e8, \u05e1\u05d1\u05d9\u05e8\u05d5\u05ea \u05d2\u05d1\u05d5\u05d4\u05d4 \u05d9\u05d5\u05ea\u05e8 \u05dc\u05d4\u05d9\u05de\u05e6\u05d0\u05d5\u05ea \u05e2\u05dc \u05d4\u05d2\u05d5 \u05d5\u05e2\u05d5\u05d1\u05d9 \u05d1\u05e8\u05e1\u05dc\u05d5 \u05d3\u05e7 \u05d9\u05d5\u05ea\u05e8. NAM \u05d4\u05d9\u05d5 \u05d1\u05e1\u05d1\u05d9\u05e8\u05d5\u05ea \u05d2\u05d1\u05d5\u05d4\u05d4 \u05e4\u05d9 2.5 \u05dc\u05d4\u05e8\u05d0\u05d5\u05ea \u05e8\u05e9\u05ea \u05e4\u05d9\u05d2\u05de\u05e0\u05d8\u05e8\u05d9\u05ea \u05e9\u05dc\u05d9\u05dc\u05d9\u05ea \u05de\u05d0\u05e9\u05e8 DNM. NAM \u05e9\u05d4\u05d9\u05d5 in situ \u05d4\u05d9\u05d5 \u05d1\u05e1\u05d1\u05d9\u05e8\u05d5\u05ea \u05d2\u05d1\u05d5\u05d4\u05d4 \u05e4\u05d9 2.1 \u05d5\u05e4\u05d9 \u05e9\u05e0\u05d9\u05d9\u05dd \u05dc\u05d4\u05e6\u05d9\u05d2 \u05d0\u05d6\u05d5\u05e8 \u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9 \u05dc\u05dc\u05d0 \u05de\u05d1\u05e0\u05d9\u05dd \u05e0\u05d9\u05ea\u05e0\u05d9\u05dd \u05dc\u05d4\u05d2\u05d3\u05e8\u05d4 \u05d5\u05d0\u05d6\u05d5\u05e8\u05d9\u05dd \u05d7\u05e1\u05e8\u05d9 \u05de\u05d1\u05e0\u05d4 \u05d7\u05d5\u05de\u05d9\u05dd \u05d1\u05d4\u05d9\u05e8\u05d9\u05dd \u05de\u05d0\u05e9\u05e8 DNM, \u05d1\u05d4\u05ea\u05d0\u05de\u05d4. \u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea in situ \u05d4\u05e6\u05d2\u05d9\u05e2\u05d5 \u05d1\u05e1\u05d1\u05d9\u05e8\u05d5\u05ea \u05d2\u05d1\u05d5\u05d4\u05d4 \u05d9\u05d5\u05ea\u05e8 \u05e8\u05e9\u05ea \u05e4\u05d9\u05d2\u05de\u05e0\u05d8\u05e8\u05d9\u05ea, \u05d5\u05de\u05dc\u05e0\u05d5\u05de\u05d5\u05ea \u05e4\u05d5\u05dc\u05e9\u05e0\u05d9\u05d5\u05ea \u05d4\u05e6\u05d9\u05d2\u05d5 \u05d1\u05d3\u05e8\u05da \u05db\u05dc\u05dc \u05d3\u05d4-\u05e4\u05d9\u05d2\u05de\u05e0\u05d8\u05e6\u05d9\u05d4 \u05d3\u05de\u05d5\u05d9\u05ea \u05e6\u05dc\u05e7\u05ea \u05d5\u05de\u05d1\u05e0\u05d9\u05dd \u05dc\u05d1\u05e0\u05d9\u05dd \u05de\u05d1\u05e8\u05d9\u05e7\u05d9\u05dd. \u05e4\u05e1\u05d9\u05dd, \u05db\u05ea\u05de\u05d9\u05dd \u05d5\u05de\u05d1\u05e0\u05d9\u05dd \u05dc\u05d1\u05e0\u05d9\u05dd \u05de\u05d1\u05e8\u05d9\u05e7\u05d9\u05dd \u05d4\u05d9\u05d5 \u05e7\u05e9\u05d5\u05e8\u05d9\u05dd \u05dc\u05e2\u05d5\u05de\u05e7 \u05d1\u05e8\u05e1\u05dc\u05d5 \u05e2\u05de\u05d5\u05e7 \u05d9\u05d5\u05ea\u05e8. \u05de\u05e1\u05e7\u05e0\u05d5\u05ea: \u05dc\u05de\u05e8\u05d5\u05ea \u05e9\u05dc\u05d0 \u05e0\u05d9\u05ea\u05df \u05d4\u05d9\u05d4 \u05dc\u05d6\u05d4\u05d5\u05ea \u05d0\u05ea \u05de\u05e8\u05db\u05d9\u05d1 \u05d4\u05e0\u05d1\u05d5\u05e1 \u05e9\u05dc NAM \u05d1\u05d0\u05d5\u05e4\u05df \u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9 \u05d1\u05e1\u05d3\u05e8\u05d4 \u05d4\u05e0\u05d5\u05db\u05d7\u05d9\u05ea, \u05e8\u05e9\u05ea \u05e4\u05d9\u05d2\u05de\u05e0\u05d8\u05d9\u05dd \u05e9\u05dc\u05d9\u05dc\u05d9\u05ea, \u05d0\u05d6\u05d5\u05e8\u05d9\u05dd \u05d7\u05e1\u05e8\u05d9 \u05de\u05d1\u05e0\u05d4 \u05d7\u05d5\u05de\u05d9\u05dd \u05d1\u05d4\u05d9\u05e8\u05d9\u05dd \u05d5\u05d0\u05d6\u05d5\u05e8\u05d9\u05dd \u05dc\u05dc\u05d0 \u05de\u05d1\u05e0\u05d9\u05dd \u05e0\u05d9\u05ea\u05e0\u05d9\u05dd \u05dc\u05d4\u05d2\u05d3\u05e8\u05d4 \u05d4\u05dd \u05e8\u05de\u05d6\u05d9\u05dd \u05d3\u05e8\u05de\u05d5\u05e1\u05e7\u05d5\u05e4\u05d9\u05d9\u05dd \u05dc- NAM.","og_url":"https:\/\/www.oferreiter.com\/en\/the-differences-in-clinical-dermoscopic-features-between-in-nevus-associated-and-de-novo-melanomas-2\/","og_site_name":"\u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8","article_published_time":"2021-11-25T07:24:00+00:00","article_modified_time":"2023-10-29T11:37:00+00:00","og_image":[{"width":800,"height":533,"url":"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2023\/03\/doctor-examines-wart-child-s-body.jpg","type":"image\/jpeg"}],"author":"newoferr_admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"newoferr_admin","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.oferreiter.com\/en\/the-differences-in-clinical-dermoscopic-features-between-in-nevus-associated-and-de-novo-melanomas-2\/#article","isPartOf":{"@id":"https:\/\/www.oferreiter.com\/en\/the-differences-in-clinical-dermoscopic-features-between-in-nevus-associated-and-de-novo-melanomas-2\/"},"author":{"name":"newoferr_admin","@id":"https:\/\/www.oferreiter.com\/en\/#\/schema\/person\/ed72a0d5185a8c3e30dc667f8b4de8a4"},"headline":"The differences in clinical &#038; 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