{"id":4380,"date":"2026-04-21T07:56:54","date_gmt":"2026-04-21T07:56:54","guid":{"rendered":"https:\/\/www.oferreiter.com\/?p=4380"},"modified":"2026-04-21T08:03:59","modified_gmt":"2026-04-21T08:03:59","slug":"importance-of-both-clinical-and-dermoscopic-findings-in-predicting-high-risk-histopathological-subtype-in-facial-basal-cell-carcinomas","status":"publish","type":"post","link":"https:\/\/www.oferreiter.com\/en\/importance-of-both-clinical-and-dermoscopic-findings-in-predicting-high-risk-histopathological-subtype-in-facial-basal-cell-carcinomas\/","title":{"rendered":"Importance of Both Clinical and Dermoscopic Findings in Predicting High-Risk Histopathological Subtype in Facial Basal Cell Carcinomas"},"content":{"rendered":"<p dir=\"ltr\">Hannah Ceder, Eva Backman, Ashfaq Marghoob, Cristi\u00e1n Navarrete-Dechent, Sam Polesie, Ofer Reiter, John Paoli<\/p>\n<p dir=\"ltr\"><strong class=\"sub-title\">Introduction:\u00a0<\/strong>Being able to recognize high-risk facial basal cell carcinoma (BCC) may lead to fewer incomplete excisions and inappropriate treatments.<\/p>\n<p dir=\"ltr\"><strong class=\"sub-title\">Objectives:\u00a0<\/strong>We sought to investigate clinical and dermoscopic criteria for predicting facial BCC subtypes, analyze the interobserver agreement between readers, and develop a diagnostic algorithm to predict high-risk histopathological subtype.<\/p>\n<p dir=\"ltr\"><strong class=\"sub-title\">Methods:\u00a0<\/strong>In this single-center, retrospective investigation, 6 independent readers evaluated predefined clinical and dermoscopic criteria in images of histopathologically verified primary facial BCCs including: topography, border demarcation, vessels, ulceration, white porcelain areas, shiny white blotches and strands, and pigmented structures and vessels within ulceration.<\/p>\n<p dir=\"ltr\"><strong class=\"sub-title\">Results:\u00a0<\/strong>Overall, 297 clinical and dermoscopic image pairs were analyzed. The strongest associations with high-risk subtype were: &#8220;bumpy&#8221; topography (OR 3.8, 95% CI, 3.1-4.7), ill-defined borders (OR 3.4, 95% CI 3.1-4.7), white porcelain area (OR 3.5, 95% CI 2.8-4.5), and vessels within ulceration (OR 3.1, 95% CI 2.4-4.1). Predominantly focused vessels were a positive diagnostic criterium for either nodular (OR 1.7, 95% CI 1.3-2.2) or high-risk (OR 2.0, 95% CI 1.6-2.5) subtypes and a strong negative diagnostic criterium for superficial BCC (OR 14.0, 95% CI 9.6-20.8). Interobserver agreement ranged from fair to substantial (\u03ba = 0.36 to 0.72). A diagnostic algorithm based on these findings demonstrated a sensitivity of 81.4% (95% CI, 78.9-83.7%) and a specificity of 53.3% (95% CI, 49.7-56.9%) for predicting high-risk BCC subtype.<\/p>\n<p dir=\"ltr\"><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>Integration of both clinical and dermoscopic features (including novel features such as topography and vessels within ulceration) are essential to improve subtype prediction of facial BCCs and management decisions.<\/p>\n<p dir=\"ltr\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-full wp-image-4378\" src=\"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2026\/04\/\u05e6\u05d9\u05dc\u05d5\u05dd-\u05de\u05e1\u05da-2026-04-21-\u05d1-10.55.05-1.png\" alt=\"\" width=\"434\" height=\"614\" srcset=\"https:\/\/www.oferreiter.com\/wp-content\/uploads\/2026\/04\/\u05e6\u05d9\u05dc\u05d5\u05dd-\u05de\u05e1\u05da-2026-04-21-\u05d1-10.55.05-1.png 434w, https:\/\/www.oferreiter.com\/wp-content\/uploads\/2026\/04\/\u05e6\u05d9\u05dc\u05d5\u05dd-\u05de\u05e1\u05da-2026-04-21-\u05d1-10.55.05-1-212x300.png 212w\" sizes=\"(max-width: 434px) 100vw, 434px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hannah Ceder, Eva Backman, Ashfaq Marghoob, Cristi\u00e1n Navarrete-Dechent, Sam Polesie, Ofer Reiter, John Paoli Introduction:\u00a0Being able to recognize high-risk facial basal cell carcinoma (BCC) may lead to fewer incomplete excisions and inappropriate treatments. Objectives:\u00a0We sought to investigate clinical and dermoscopic criteria for predicting facial BCC subtypes, analyze the interobserver agreement between readers, and develop a [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4380","post","type-post","status-publish","format-standard","hentry","category-published-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Importance of Both Clinical and Dermoscopic Findings in Predicting High-Risk Histopathological Subtype in Facial Basal Cell Carcinomas - \u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.oferreiter.com\/en\/importance-of-both-clinical-and-dermoscopic-findings-in-predicting-high-risk-histopathological-subtype-in-facial-basal-cell-carcinomas\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Importance of Both Clinical and Dermoscopic Findings in Predicting High-Risk Histopathological Subtype in Facial Basal Cell Carcinomas - \u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8\" \/>\n<meta property=\"og:description\" content=\"Hannah Ceder, Eva Backman, Ashfaq Marghoob, Cristi\u00e1n Navarrete-Dechent, Sam Polesie, Ofer Reiter, John Paoli Introduction:\u00a0Being able to recognize high-risk facial basal cell carcinoma (BCC) may lead to fewer incomplete excisions and inappropriate treatments. Objectives:\u00a0We sought to investigate clinical and dermoscopic criteria for predicting facial BCC subtypes, analyze the interobserver agreement between readers, and develop a [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.oferreiter.com\/en\/importance-of-both-clinical-and-dermoscopic-findings-in-predicting-high-risk-histopathological-subtype-in-facial-basal-cell-carcinomas\/\" \/>\n<meta property=\"og:site_name\" content=\"\u05d3&quot;\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8\" \/>\n<meta property=\"article:published_time\" content=\"2026-04-21T07:56:54+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-21T08:03:59+00:00\" \/>\n<meta name=\"author\" content=\"ofer-r\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"ofer-r\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.oferreiter.com\/en\/importance-of-both-clinical-and-dermoscopic-findings-in-predicting-high-risk-histopathological-subtype-in-facial-basal-cell-carcinomas\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.oferreiter.com\/en\/importance-of-both-clinical-and-dermoscopic-findings-in-predicting-high-risk-histopathological-subtype-in-facial-basal-cell-carcinomas\/\"},\"author\":{\"name\":\"ofer-r\",\"@id\":\"https:\/\/www.oferreiter.com\/en\/#\/schema\/person\/29e63728a19c29c75570d11d7116e8f1\"},\"headline\":\"Importance of Both Clinical and Dermoscopic Findings in Predicting High-Risk Histopathological Subtype in Facial Basal Cell Carcinomas\",\"datePublished\":\"2026-04-21T07:56:54+00:00\",\"dateModified\":\"2026-04-21T08:03:59+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.oferreiter.com\/en\/importance-of-both-clinical-and-dermoscopic-findings-in-predicting-high-risk-histopathological-subtype-in-facial-basal-cell-carcinomas\/\"},\"wordCount\":258,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.oferreiter.com\/en\/#organization\"},\"articleSection\":[\"Published Research\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.oferreiter.com\/en\/importance-of-both-clinical-and-dermoscopic-findings-in-predicting-high-risk-histopathological-subtype-in-facial-basal-cell-carcinomas\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.oferreiter.com\/en\/importance-of-both-clinical-and-dermoscopic-findings-in-predicting-high-risk-histopathological-subtype-in-facial-basal-cell-carcinomas\/\",\"url\":\"https:\/\/www.oferreiter.com\/en\/importance-of-both-clinical-and-dermoscopic-findings-in-predicting-high-risk-histopathological-subtype-in-facial-basal-cell-carcinomas\/\",\"name\":\"Importance of Both Clinical and Dermoscopic Findings in Predicting High-Risk Histopathological Subtype in Facial Basal Cell Carcinomas - 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