{"id":4411,"date":"2026-04-21T09:30:45","date_gmt":"2026-04-21T09:30:45","guid":{"rendered":"https:\/\/www.oferreiter.com\/?p=4411"},"modified":"2026-04-21T09:31:19","modified_gmt":"2026-04-21T09:31:19","slug":"omparative-and-complementary-diagnostic-value-of-dermatoscopy-and-clinical-close-up-photography-in-skin-cancer-diagnosis-a-study-from-the-milk10k-dataset","status":"publish","type":"post","link":"https:\/\/www.oferreiter.com\/en\/omparative-and-complementary-diagnostic-value-of-dermatoscopy-and-clinical-close-up-photography-in-skin-cancer-diagnosis-a-study-from-the-milk10k-dataset\/","title":{"rendered":"omparative and Complementary Diagnostic Value of Dermatoscopy and Clinical Close-up Photography in Skin Cancer Diagnosis: A Study from the MILK10k Dataset"},"content":{"rendered":"
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Christoph M\u00fcller<\/a>\u00a0<\/span>1<\/a><\/sup>,\u00a0<\/span><\/span>Anna Wolber<\/a>\u00a0<\/span>2<\/a><\/sup>,\u00a0<\/span><\/span>Aimilios Lallas<\/a>\u00a0<\/span>3<\/a><\/sup>,\u00a0<\/span><\/span>Giuseppe Argenziano<\/a>\u00a0<\/span>4<\/a><\/sup>,\u00a0<\/span><\/span>Iris Zalaudek<\/a>\u00a0<\/span>5<\/a><\/sup>,\u00a0<\/span><\/span>H Peter Soyer<\/a>\u00a0<\/span>6<\/a><\/sup>,\u00a0<\/span><\/span>Susana Puig<\/a>\u00a0<\/span>7<\/a><\/sup>,\u00a0<\/span><\/span>Bengu Nisa Akay<\/a>\u00a0<\/span>8<\/a><\/sup>,\u00a0<\/span><\/span>Ana Maria Forsea<\/a>\u00a0<\/span>9<\/a><\/sup>,\u00a0<\/span><\/span>Josep Malvehy<\/a>\u00a0<\/span>10<\/a><\/sup>,\u00a0<\/span><\/span>Ashfaq Marghoob<\/a>\u00a0<\/span>11<\/a><\/sup>,\u00a0<\/span><\/span>Zoe Apalla<\/a>\u00a0<\/span>12<\/a><\/sup>,\u00a0<\/span><\/span>Cliff Rosendahl<\/a>\u00a0<\/span>13<\/a><\/sup>,\u00a0<\/span><\/span>Konstantinos Liopyris<\/a>\u00a0<\/span>14<\/a><\/sup>,\u00a0<\/span><\/span>Ofer Reiter<\/a>\u00a0<\/span>15<\/a><\/sup>,\u00a0<\/span><\/span>Caterina Longo<\/a>\u00a0<\/span>16<\/a><\/sup>,\u00a0<\/span><\/span>Philipp Tschandl<\/a>\u00a0<\/span>17<\/a><\/sup>,\u00a0<\/span><\/span>Harald Kittler<\/a>\u00a0<\/span>17<\/a><\/sup><\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/header>\n
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Abstract<\/h2>\n
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Background:\u00a0<\/strong>While dermatoscopy’s added value to clinical imaging is known, the standalone value of dermatoscopy and clinical images remains unclear.<\/p>\n

Objective:\u00a0<\/strong>To quantify the standalone and complementary value of dermatoscopy and clinical close-up imaging across lesion types and reader expertise.<\/p>\n

Methods:\u00a0<\/strong>In an online reader study, 283 participants diagnosed 1,567 paired images (clinical close-up\/dermatoscopic) of skin cancers and mimics. The presentation order was randomized. Diagnostic accuracy, sensitivity, and specificity were compared. The effects of modality, reader expertise, and presentation order were analysed using a generalized linear mixed model.<\/p>\n

Results:\u00a0<\/strong>Dermatoscopy alone showed higher sensitivity (85.0% vs. 74.2%) but lower specificity (66.8% vs. 71.9%) compared with clinical close-up images alone. It improved accuracy for melanoma and basal cell carcinoma, but not for nevi. Adding either modality increased the odds of a correct diagnosis. Dermatoscopy raised the odds by 52% (OR=1.52; 95%CI:1.36-1.70;p<0.001), while clinical close-ups increased the odds by 40% (OR=1.40;95%CI:1.20-1.61;p<0.001).<\/p>\n

Limitations:\u00a0<\/strong>Image-based evaluation simulated teledermatology rather than face-to-face assessment; potential selection and verification bias cannot be excluded.<\/p>\n

Conclusion:\u00a0<\/strong>Dermatoscopy alone yields higher sensitivity for malignant lesions but lower specificity for nevi than clinical close-up images. The latter provides complementary diagnostic cues, underscoring the value of integrating both modalities for optimal assessment.<\/p>\n<\/div>\n

Keywords:\u00a0<\/strong>Dermatoscopy; Diagnostic accuracy; Sensitivity; Skin cancer; Specificity; diagnostic modality.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Christoph M\u00fcller\u00a01,\u00a0Anna Wolber\u00a02,\u00a0Aimilios Lallas\u00a03,\u00a0Giuseppe Argenziano\u00a04,\u00a0Iris Zalaudek\u00a05,\u00a0H Peter Soyer\u00a06,\u00a0Susana Puig\u00a07,\u00a0Bengu Nisa Akay\u00a08,\u00a0Ana Maria Forsea\u00a09,\u00a0Josep Malvehy\u00a010,\u00a0Ashfaq Marghoob\u00a011,\u00a0Zoe Apalla\u00a012,\u00a0Cliff Rosendahl\u00a013,\u00a0Konstantinos Liopyris\u00a014,\u00a0Ofer Reiter\u00a015,\u00a0Caterina Longo\u00a016,\u00a0Philipp Tschandl\u00a017,\u00a0Harald Kittler\u00a017 Abstract Background:\u00a0While dermatoscopy’s added value to clinical imaging is known, the standalone value of dermatoscopy and clinical images remains unclear. Objective:\u00a0To quantify the standalone and complementary value of dermatoscopy and clinical close-up imaging […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4411","post","type-post","status-publish","format-standard","hentry","category-published-research"],"yoast_head":"\nomparative and Complementary Diagnostic Value of Dermatoscopy and Clinical Close-up Photography in Skin Cancer Diagnosis: A Study from the MILK10k Dataset - \u05d3"\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.oferreiter.com\/en\/omparative-and-complementary-diagnostic-value-of-dermatoscopy-and-clinical-close-up-photography-in-skin-cancer-diagnosis-a-study-from-the-milk10k-dataset\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"omparative and Complementary Diagnostic Value of Dermatoscopy and Clinical Close-up Photography in Skin Cancer Diagnosis: A Study from the MILK10k Dataset - \u05d3"\u05e8 \u05e2\u05d5\u05e4\u05e8 \u05e8\u05d9\u05d9\u05d8\u05e8 \u05d0\u05d2\u05e8\" \/>\n<meta property=\"og:description\" content=\"Christoph M\u00fcller\u00a01,\u00a0Anna Wolber\u00a02,\u00a0Aimilios Lallas\u00a03,\u00a0Giuseppe Argenziano\u00a04,\u00a0Iris Zalaudek\u00a05,\u00a0H Peter Soyer\u00a06,\u00a0Susana Puig\u00a07,\u00a0Bengu Nisa Akay\u00a08,\u00a0Ana Maria Forsea\u00a09,\u00a0Josep Malvehy\u00a010,\u00a0Ashfaq Marghoob\u00a011,\u00a0Zoe Apalla\u00a012,\u00a0Cliff Rosendahl\u00a013,\u00a0Konstantinos Liopyris\u00a014,\u00a0Ofer Reiter\u00a015,\u00a0Caterina Longo\u00a016,\u00a0Philipp Tschandl\u00a017,\u00a0Harald Kittler\u00a017 Abstract Background:\u00a0While dermatoscopy’s added value to clinical imaging is known, the standalone value of dermatoscopy and clinical images remains unclear. 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